Notable SCI & CNS/D Researchers - Cure Medical

Notable SCI & CNS/D Researchers

News for the Cure Nation logoCure Medical proudly upholds the unsurpassed Cure Commitment to support medical research. That means, when you choose to use or recommend a Cure Medical product, you participate in advancing efforts toward a cure for SCI and CNS/D.

In addition to spinal cord injury, there are many different disorders of the Central Nervous System (CNS). Common ones include:

  • Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, 
  • Multiple Sclerosis (MS),
  • Post-Polio,
  • Spina Bifida,
  • Transverse Myelitis

Through our ongoing financial commitment, Cure Medical supports the latest advances in science and medicine related to SCI and CNS/D.

We think these scientists below and their work in these areas are worth noting.

Michael Beattie, UCSF

Michael Beattie studies cell death after spinal cord injury. He also explores the use of stem cells transplanted into the spinal cord.

Dr. Michael Beattie with his wife, Dr. Jacqueline Bresnahan

Dr. Michael Beattie with his wife, Dr. Jacqueline Bresnahan

Dr. Beattie has been interested in the neural mechanisms of recovery after brain and spinal cord injury for many years. He and his wife and collaborator, Dr. Jacqueline Bresnahan (also a member of the Neurosurgery faculty), have recently moved their laboratory to the Brain and Spinal Injury Center (BASIC) at UCSF from Ohio State University. Their group is known for developing preclinical models to study recovery of function after spinal cord injury, and for studies of the biology of neural injury and repair.

See Full Bio + Contact Dr. Beattie here. 

Jacqueline C. Bresnahan, UCSF

Jacqueline Bresnahan examines what happens after nerve and support cell injury, as well as how the nervous system regenerates and repairs itself.

Dr. Bresnahan’s research focuses on understanding the biological underpinnings of neurotrauma, particularly spinal cord injury, with the goal of improving recovery for individuals who suffer damage to the nervous system. Her laboratory has developed a number of models to study cellular systems and behavioral changes that occur as a consequence of injury.

Her major research interests are cell death mechanisms, including excitotoxicity; regeneration and repair (especially of oligodendrocytes — the glial cells that produce myelin); neuroprotection; transplantation; and mechanisms of functional recovery after cervical spinal cord injury in both rodent and primate models.

See Full Bio + Contact Dr. Bresnahan here.

Dr. James Fawcett

Dr. James Fawcett

James Fawcett, University of Cambridge

James Fawcett is exploring a number of ways to regenerate injured nerves through the scar that forms in the spinal cord after injury.

Axon regeneration in the damaged CNS: Regeneration of axons after CNS damage is blocked by several molecules in the environment and by loss of intrinsic regeneration ability, Dr. Fawcett aims to modify the environment to make it more permissive and modify axonal properties to improve regeneration.

Plasticity is the main mechanism for functional recovery after damage to the nervous system. In childhood plasticity is largely turned off by extracellular matrix structures called perineeuronal nets. By moduating their function, we can improve functional recovery and memory in the adult CNS.

Interfacing the nervous system with electronics: Dr. Fawcett’s team is developing a microchannel interface prosthesis which allows permanent extracellular recording from axons.

This technology is being developed for control of bladder function in paralyzed human and veterinary patients, and for controlling prosthetic limbs.

See Full Bio + Contact Dr. Fawcett here.

Dr. Zhigang He

Dr. Zhigang He

Zhigang He, Harvard University

Zhigang He is interested in understanding the cellular and molecular mechanisms involved in axon degeneration and regeneration.

Restoring lost function after spinal cord injury or other types of CNS injuries is one of the major challenges of contemporary neuroscience. Functional deficits after such injuries are primarily due to a disruption of axonal connections. Thus, to restore motor function after injury, what is needed is regeneration of the severed axons of long fiber tracts in order to re-establish the disrupted connections.

In order to repair the damaged supraspinal tracts, the injured neurons first need to recover the capacity for intrinsic growth, initiating regenerative growth. Sufficient numbers of regenerating axons then have to cross the lesion site and remake functional synapses with neurons in the caudal spinal cord.

Dr. He’s recent studies have led to the development of novel and effective genetic methods (deletion of PTEN and/or SOCS3) for re-activating neuronal regenerative capacity and thereby allowing for robust regenerative growth after injury, representing a major achievement in the first step of neural repair.

See Full Bio + Contact Dr. He here.

Stephen McMahon, Kings College London

Dr. Stephen McMahon is Sherrington Professor of Physiology at King’s College London, and Director of the London Pain Consortium. He is a neuroscientist who trained with Patrick Wall in the 1980s. He is principally interested in somatosensory systems and actively engaged in work ranging from molecular biology to electrophysiology to human psychophysical studies. He has published more than 250 original research articles, many highly rated (H-index >80) and is co-editor of the Textbook of Pain.

Dr. McMahon has shown that degrading one component of the post-injury scar enables regeneration of damaged central nerves and restores some sensory and movement behaviors. His research areas include behavioural, electrophysiological and anatomical studies of somatosensory systems, particularly pain; and spinal cord injury.

Dr. Stephen McMahon

Spinal cord injury & pain

There are no effective treatments to promote the repair of spinal cord injuries, so sufferers face a lifetime of  disability.  Many also experience chronic pain. Dr. McMahon’s team is currently exploring a number of approaches to repair spinal cord injuries.

They have shown, in preclinical models, that one form of spinal injury – avulsion of nerve roots – can be treated with neurotrophic factors. These factors are insufficient to repair injures of the spinal cord itself. An important reason seems to be the inhibitory nature of the glial scar that forms at the site of central nervous system lesions.

See Full Bio + Contact Dr. McMahon here.

Jerry Silver, Case Western Reserve University

Dr. Jerry Silver is currently Professor in the Department of Neurosciences at the Case Western Reserve University School of Medicine and adjunct Professor in the Department of Neurosurgery at the Cleveland Clinic Foundation.

Jerry Silver studies the molecules that influence developing and regenerating axons along their proper pathways within the brain and spinal cord.

Dr. Jerry Silver

The ultimate goal of the Silver lab is to understand the basic biology that underlies axonal dieback and regeneration failure in the adult spinal cord and then use this knowledge to develop strategies to maximally overcome the lack of regeneration after both incomplete and complete cord injury in order to promote functional repair. Although highly controversial from its inception, the Silver lab was one of the very first to suggest that overtly growth-repulsive environments, whose function was to actively turn axons away from improper trajectories during embryogenesis, might reappear in the injured CNS and block the attempt of severed axons to re-grow.

The lab’s research strategy shows clearly, for the first time, that long distance regeneration, with appropriate re-formation of functional connections, can be achieved in the adult after catastrophic spinal cord injury providing real hope that we are now entering an era where strategies for providing functional benefit in models of spinal cord injury are sufficiently robust that there should be optimism for translational success.

See Full Bio + Contact Dr. Silver here.

Oswald Steward, UC Irvine
Oswald Steward, PhD

Dr. Oswald Steward

Oswald Steward, PhD, is the UC Irvine School of Medicine’s senior associate dean for research and director of the Reeve-Irvine Research Center. In addition to his leadership responsibilities, Dr. Steward studies the molecular mechanisms of spinal cord axon regeneration as well as animal models of spinal cord injury.

Almost 25 years ago, Steward discovered that polyribosomes were selectively localized just beneath postsynaptic membrane specializations on the dendrites of CNS neurons. Polyribosomes are collections of ribosomes that are actively engaged in synthesizing protein. They are the basic machinery of protein synthesis.

Steward’s current research assesses how particular mRNAs are targeted to individual synaptic sites on neuronal dendrites.

See Full Bio + Contact Dr. Steward here.

Marc Tessier-Lavigne, Stanford University

Marc Trevor Tessier-Lavigne FRS FRSC FMedSci is a French-Canadian neuroscientist who is the 11th president of Stanford University. Previously, he was president of Rockefeller University in New York City. In that capacity, he led a premier biomedical research and graduate education institution, for the past five years.

Nationally and internationally, Tessier-Lavigne has been a tireless advocate for societal support of science, including testifying before Congress on the need for federal funding of research. He has been a champion of growing the New York bioscience community, partnering with other academic medical institutions to help establish the New York Genome Center and working with the New York City government and private sector to stimulate biomedical industry development.

Marc Trevor Tessier-Lavigne FRS FRSC FMedSci

Throughout his administrative tenures, Tessier-Lavigne has remained active in teaching and research in his field of neuroscience, where he is a world leader in the study of brain development and repair. His research has focused on the cause and treatment of degenerative brain diseases such as Alzheimer’s and Parkinson’s, as well as on therapies for spinal cord injuries. His seminal discoveries in the biology of the nervous system revealed how neural circuits in the brain form during embryonic development.

Dr. Tessier-Lavigne’s laboratory investigates how neural circuits in the brain form during embryonic development.

Full Bio + Contact Dr. Tessier-Lavigne

Mark Tuszynski, UC San Diego
Mark H. Tuszynski, MD, PhD

Mark H. Tuszynski, MD, PhD

Mark Tuszynski uses the genes of nerve growth factors to stimulate regeneration in the injured spinal cord.

Dr. Tuszynski’s research bridges basic mechanisms of neurobiological function and clinical translation. He initiated the first human trial of gene therapy for an adult neurodegenerative disorder — Alzheimer’s disease (AD) — in April 2001. In that study, he delivered human nerve growth factor to the cholinergic basal forebrain to determine whether cholinergic cell loss can be reduced and cholinergic function amplified in people with AD.

Dr. Tuszynski’s Spinal Cord Injury (SCI) Hypothesis is that combinatorial therapeutic strategies can enhance axonal plasticity and regeneration after acute and chronic SCI.

The failure of the spinal cord to regenerate after injury is caused by (1) lack of production of growth-promoting substances such as growth factors in the injury site, (2) lack of permissive bridges for axon growth within injury sites, (3) deficiency of strong signals for the injured cell to re-enter an active growth state, and (4) blockade of growth by inhibitors in the injured region.

This research program tests the ability of cells and growth factors to promote regeneration after SCI. Tested cells include stem cells, autologous bone marrow cells, Schwann cells, and fibroblasts. The Tuszynski group is examining both acute and chronic models of SCI.

See Full Bio + Contact Dr. Tusynski
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“The only true relief from SCI is through the development of a cure.” ~Bob Yant, Cure Medical Founder and Cure Catheter user

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